The Italian Ministry of Health, in 2002, instructed the National Committee for Bioethics to carefully review and ultimately provide evidence for future legislative bills in various aspects.One such matter was that of the subject of "Pet Therapy", generically viewed as a "man-animal" relationship, with the purpose of proving beneficiary to both HR T
Objective: to present specific recommendations in the preparation and administration of anti-infective medications via the gastrostomy catheter in the Emergency Unit Gin Glasses of a University Hospital in the South of Brazil.Method: a descriptive-exploratory, cross-sectional, qualitative-quantitative study conducted between April and October 2015.
Summary: CHK1 inhibitors exhibit dose-limiting toxicity despite potent tumor cytotoxicity in clinical trials.Here, we reveal that low-dose prexasertib induces mtDNA damage by impairing repair machinery, triggering cytosolic mtDNA release via VDAC1 to activate STING-mediated innate immunity.Mechanistically, prexasertib blocks CHK1 phosphorylation an
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